Pulp canal obliteration was radiographically observed in 10/56 (17.9%) and 7/56 (12.5%) cases in the BiodentineTM and formocresol groups, respectively. Available from: http://www.tricornet.com/nioshdbs/idlh/50000.htm [Last accessed 2006 on Mar 13]. Preservation, the retention of maximum vital tissue with no … The current study has some limitations, the limited available time for follow up, strict inclusion criteria for selecting participants. Pulpotomy of human primary molars … Tissue changes induced by the absorption of formocresol from pulpotomy sites in dogs. Scand J Dent Res 1976;84:345-7. J Dent Med Sci. Although the number of participants was sufficient, it is premature to draw a final conclusion, because of the short follow–up period. A 2-year follow-up of primary molars, pulpotomized with a gentle technique and capped with calcium hydroxide. World Health Organization. Clinical calibration results by the 2 examiners were considered excellent (k=0.98). One patient with 4 (3.6%) pulpotomized teeth (2 pairs) was unavailable for the 12–month evaluation. Initially, the technique involved five visits. Fuks AB, Holan G, Davis JM, Eidelman E. Ferric sulfate versus dilute formocresol in pulpotomized primary molars: Long-term follow up. In our study, the success rate of BiodentineTM (100%) was comparable to the success rate reported in previous studies [14, 36]. Each parent signed an informed consent for the child’s participation in the study. ASDC J Dent Child 1993;60:107-14. J Endod 1989;15:302-5. Article  Introduction. Various in vitro and in vivo researches have confirmed the bioactivity of BiodentineTM, also its outstanding performance in vital pulp treatment [12,13,14]. The effects of laser irradiation on the activation of inflammatory cells and the vital pulpotomy. 153. Because of its regenerative properties, it was suggested to be used as a suitable replacement to formocresol in pulpotomy of primary teeth [31]. Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation. Inter– and intra–examiner agreement was performed using the Kappa statistic. Recently, most studies have concentrated on comparing formocresol to mineral trioxide aggregate (MTA) and Bioaggregate (BA) for human primary teeth pulpotomy [18,19,20]. Due to its excellent characteristics, in addition, its capability to control the disadvantages of both formocresol and MTA, BiodentineTM could be an excellent replacement to the current materials for pulp therapy. This current randomized, split–mouth clinical study is considered as one of the few prospective clinical trials that used BiodentineTM in pulpotomy of primary molars in children. Extended follow-up of a cohort of British chemical workers exposed to formaldehyde. Oral Surg Oral Med Oral Pathol 1971;31:571-85. Sopot, Poland: 12th congress of EAPD; 2014. In: Ingle J, Bakland L, editors. Garcia-Godoy F, Ranly DM. Magnusson B. J Endod. Berger JE. Squire RA, Cameron LL. Part of Int J Surg. Miserendino LJ, Neiburgerr EJ, Walia H, Luebke N, Brantley W. Thermal effects on continuous wave CO2 laser exposure on human teeth: An in vitro study. 2. Since BiodentineTM showed success in many endodontic procedures and used as a permanent dentine substitute, the pulp chamber was filled up to the occlusal level with BiodentineTM [32]. PCO results from vigorous odontoblastic activity and indicate pulpal vitality. Effects of selected inflammatory mediators in blood flow and vascular permeability in the dental pulp. Eur J Paediatr Dent 2005;6:133-8. Carcinogenesis 2000;21:1573-80. Pediatr Dent 2000;22(4):278-86. Due to this, many medicaments have been prepared, examined and systemized as possible replacements for formocresol [6]. Odont Revy 1970;21:415-31. Jukiæ S, Aniæ I, Koba K, Najzar-Fleger D, Matsumoto K. The effect of pulpotomy using CO2 and Nd: YAG lasers on dental pulp tissue. Pediatr Dent. Eur Arch Paediatr Dent. This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia under grant no. Van Hassell HJ. Buckley's formocresol was mutagenic for one patient in an in vivo study to lymphocyte cultures obtained from the peripheral blood, raising doubt about the desirability of its use for pulpotomies in children. Current concepts in vital pulp therapy. J Pedod 1982;6:203-17. Ranly DM. Fuks A, Bimstein E, Klein H, Guelmann M. Assessment of a 2% buffered glutaraldehyde solution in pulpotomized primary teeth of school children. Pract Periodontics Aesthet Dent 1998;10:621-4. Mineral trioxide aggregate as a pulpotomy agent in primary molars: An in vivo study. 2012;38:1220–6. Pediatr Dent. J Am Dent Assoc 1984;108:775-8. J Res Med Sci 2004;6:304-7. Oztas N, Ulusu T, Gygur T, Cokpekin F. Comparison of electrosurgery and formocresol as pulpotomy techniques in dog primary teeth. Scand J Dent Res 1978;86:273-8. Jabbarifar SE, Khademi AA, Ghasemi D. Success rate of formocresol pulpotomy versus mineral trioxide aggregate in human primary molar tooth. Endodontics. Most read articles by the same author(s) Prachi Goyal, I K Pandit, Neeraj Gugnani, Monika Gupta, Neha Singla, Vikas Singla, CLINICAL EFFICACY OF VARIOUS MEDICAMENTS USED FOR PULPOTOMY IN PRIMARY MOLARS – A COMPARATIVE STUDY , International Journal of Research and Development in Pharmacy & Life Sciences: Vol. Pediatr Dent 2001;23:15-8. A systematic literature review Med Oral Patol Oral Cir Bucal. At 6 and 12 months in both materials, PCO was the only radiographic finding detected in 15.2% (17/112) of all teeth. Coll JA, Seale NS, Vargas K, Marghalani AA, Al Shamali S, Graham L. Primary tooth vital pulp therapy: a systematic review and meta–analysis. Is formocresol obsolute? Pulpal regeneration. The pulpotomy procedure involves covering pulp stumps with a pulp-capping agent to promote healing … J Clin Pediatr Dent 2001;26:81-5. Formocresol is a long–term clinically–successful medicament for use in the pulpotomy procedure, mostly due to its excellent clinical success and ease in use [ 2 ]. Effects of mineral trioxide aggregate and formocresol on vital pulp after pulpotomy of primary molars: an in vivo study. Effectiveness of BiodentineTM versus formocresol as dressing agents in pulpotomized primary molars: preliminary results. An envelope was for each block of two contralateral teeth (one pair). Sonmez D, Sari S, Cetinbas T. A comparison of four pulpotomy techniques in primary molars: a long-term follow–up. Rolling I, Thulin H. Allergy tests against formaldehyde, cresol, and eugenol in children with pulpotomized primary teeth. Preoperative periapical radiographs of the molars considered for treatment were taken using the XCP extension cone paralleling technique. Environ Mol Mutagen 1988;12:155-66. An operator performed the pulpotomy procedures. Havale R, Anegundi RT, Indushekar K, Sudha P. Clinical and radiographic evaluation of pulpotomies in primary molars with formocresol, glutaraldehyde and ferric sulphate. 2018; © Journal of Restorative Dentistry | Published by Wolters Kluwer -. Therapeutic pulpotomy in primary molars with formocresol technique- clinical and histological follow-up. California Privacy Statement, Comparison of electrosurgical and formocresol pulpotomy procedures in children. Periapical radiographs showing successful BiodentineTM pulpotomy of tooth 65 and formocresol pulpotomy of tooth 55 (maxillary second primary molars). J Calif Dent Assoc. 2005;29:307–11. Allergy 2003;58:668-71. Spedding RH, Mitchell DF, McDonald RE. Garcia-Godoy F. A comparison between zinc oxide-eugenol and polycarboxylate cements on formocresol pulpotomies. 2019; 37(4): 327. Bahrololoomi Z, Moeintaghavi A, Emtiazi M, Hosseini G. Clinical and radiographic comparison of primary molars after formocresol and electrosurgical pulpotomy: A randomized clinical trial. 6 or no. Furthermore, this high success rate of formocresol is not in agreement with the results of other studies [34, 35]; because those studies had smaller sample sizes. Clin Oral Investig. 1990;57:371–5. Myers DR, Shoaf HK, Dirksen TR, Pashley DH, Whitford GM, Reynolds KE. 2010 Nov 1;15(6):e942-6. The radiographic and clinical evaluation of treatment outcomes was performed at 12 and 24 months post-operatively. Unfortunately, operator blinding was not possible as both materials were of different types, which required different manipulations, thus the operators’ cognitive bias could not be eliminated during the procedures but not in the follow–up evaluations. Also, formocresol is used for pulpotomies of primary teeth in Pediatric Dental Clinics, Faculty of Dentistry, KAU, Jeddah. J Pedod 1989;13:314-22. Schulz KF, Altman DG, Moher D, CONSORT Group. G–17–165–38. Available from: http://www.oecd.org/dataoecd/24/22/31744923.pdf [Last accessed on 2007 Mar 13]. Several studies have been done to investigate the risk of exposure to formocresol because it has mutagenic, toxic and carcinogenic risks in humans [3,4,5]. Ranly DM, García-Godoy F. Reviewing pulp treatment for primary teeth. Pross HF, Day JH, Clark RH, Lees RE. Thus, the final sample size for this study was calculated to be 112 teeth. Formocresol pulpotomy has remained a treatment of choice in primary teeth and is widely accepted1. INTRODUCTION. Niranjani K, Prasad MG, Vasa AA, Divya G, Thakur MS, Saujanya K. Clinical evaluation of success of primary teeth pulpotomy using mineral trioxide aggregate(®), laser and Biodentine(TM) – an in vivo study. The effects of various concentrations and lengths of application of glutaraldehyde on monkey pulp tissue. Formocresol is a long–term clinically–successful medicament for use in the pulpotomy procedure, mostly due to its excellent clinical success and ease in use [2]. Group I comprised 56 molars treated with BiodentineTM (experimental). Box 1666, AlRass, 51921, Qassim, Kingdom of Saudi Arabia, You can also search for this author in Ibricevic H, Al-Jame Q. Ferric sulphate and formocresol in pulpotomy of primary molars: Long term follow up study. Bhatt HS, Lober SB, Combes B. Fuks AB, Bimstein E, Guelmann M, Klein H. Assessment of a 2 percent buffered glutaraldehyde solution in pulpotomized primary teeth of school children. et al. Priyalakshmi S, Ranjan M. Review on BiodentineTM–a bioactive dentin substitute. Acta Odontol Pediatr 1984;5:93-8. 2015;41:1969–74. Ethical approval was obtained from the Research Ethics Committee, Faculty of Dentistry, KAU, Jeddah, Kingdom of Saudi Arabia (Approval no. Both BiodentineTM and formocresol pulpotomy techniques demonstrated favorable clinical and radiographic outcomes over a 12-month period without any significant difference. Int Endod J 1991;24:279-89. 2020; 13(3): 240, Journal of Indian Society of Pedodontics and Preventive Dentistry. Markovic D, Zivojinovic V, Vucetic M. Evaluation of three pulpotomy medicaments in primary teeth. Pesq Bras Odontoped Clin Integr 2017, 17(1):e3794 3 After local anesthesia administration and rubber dam isolation, the involved teeth indicated for pulpotomy were treated by complete removal of residual caries by using handpiece with a round bur and access to the coronal pulp was obtained. By using this website, you agree to our Pulp therapy for primary and immature permanent teeth. Selection of the method used in vital pulp therapy relies on the degree of inflammation of the pulp. Huang TH, Ding SJ, Hsu TZ, Lee ZD, Kao CT. Root canal sealers induce cytotoxicity and necrosis. Sweet reduced the number of visits over the years, because of economic and behavior management considerations. After application of topical anesthesia (Beutlich LP Pharmaceuticals, USA), local anesthesia was administrated using 27–gauge short needles and syringes loaded with carpules, each one contained 1.8 ml of Lidocaine 2% with epinephrine concentration of 1:100000 (Octocaine® 100, Novocol Healthcare Inc. Cambridge, Ontario, Canada). In: Duggal MS, editor. Purpose: The study evaluated the effects of 3 percent sodium hypochlorite (NaOCl) and formocresol (FC) as pulp dressing agents in pulpotomized primary molars. Ranly DM. Jabbarifar S, Khademi A, Ghasemi D. Success rate of formocresol versus mineral trioxide aggregate in human primary molar tooth. Milnes AR. Within a … Therefore, BiodentineTM could a good replacement to the current medicaments for regeneration of dentin–pulp complex [7]. Bakland LK. 2017;39:284–8. 5 No. Seow WK, Thong YH. 2018;40:343–51. All the teeth received stainless steel crown after … Several studies have been done to investigate the risk of exposure to formocresol because it has mutagenic, toxic and carcinogenic risks in humans [ 3, 4, 5 ]. Cytotoxicity of glutaraldehyde and formaldehyde in relation to time of exposure and concentration. Bhavya B, Sadique M, Simon EP, Ravi SV, Lal S. Spectrophotometric analysis of coronal discoloration induced by white mineral trioxide aggregate and BiodentineTM: an in vitro study. Biodentine used as a pulp-capping agent in primary pig teeth. Group II comprised 56 molars treated with formocresol (control). A pulpotomy can be done to both permanent and temporary teeth. The aim of this study was to evaluate and compare, both clinically and radiographically, the effects of calcium silicate-based materials (i.e., ProRoot MTA [PR-MTA], MTA-Plus [MTA-P], and Biodentine [BD]) and ferric sulfate [FS] in pulpotomy of primary molars.Materials and Methods. Sushynski J, Zealand C, Botero TM, Boynton JR, Majewski RF, Shelburne CE, Hu JC. Its use in primary molars was not advocated until 1930 (3). Lloyd JM, Seale NS, Wilson CF. There were no significant differences in clinical and radiographic success rates between BiodentineTM and formocresol. In addition to the findings of clinical follow--radiographic and taking into account the potential toxicity of formocresol suggest the use of mineral trioxide aggregate pulpotomy of primary tee … Mineral trioxide aggregate in primary teeth pulpotomy. The study was conducted on 33 primary teeth of three mongrel dogs between the ages of one to three months. The prevalence of IgE sensitization to formaldehyde in asthmatic children. Holan G, Eidelman E, Fuks A. Long–term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. J Endod 1987;13:500-5. Eur J Paediatr Dent. PCO was observed in 10/56 cases (17.8%) in the BiodentineTM group, and in 7/56 cases (12.5%) in the formocresol group. Pediatr Dent 1983;59:6-8. Sample size calculation for binary outcome equivalence trials was calculated using sample size calculators of a sealed envelope, randomization and online databases for clinical trials at https://www.sealedenvelope.com/power/binary-equivalence/. In both groups, all teeth were finally restored using a stainless steel crown (SSC) (3M/ESPE, St. Paul, Minn., USA). Oral Surg Oral Med Oral Pathol 1971;32:126-34. 2015;40:276–85. 2012;34(7):e202-e208. Is there life after Buckley's formocresol? BMC Oral Health 19, 3 (2019). Teeth were selected based upon the following clinical and radiographic criteria: Clinically, the study included teeth with restorable crowns, teeth with pathologic carious or mechanical exposure of vital pulps and teeth with no clinical symptoms or evidence of pulp degeneration, such as spontaneous or nocturnal pain, pain on percussion, history of swelling, or sinus tracts and teeth with no tenderness to percussion, physiologic or pathologic mobility. Data were collected, tabulated and analyzed using Fisher exact and McNemar tests. Pediatr Dent 1987;9:144-6. J Endod 2008;34:S18-24. J Am Dent Assoc 1991;122:83-5. J Calif Dent Assoc. As the split–mouth method was carried out, no difference between both groups (BiodentineTM and formocresol) concerning the patient’s age at the treatment time, gender and in the kind of molar treated was found. If the roots haven't finished forming yet, a partial pulpotomy might give it a chance to finish forming. Two full–time pediatric dentistry faculty members (other than the operator) from KAU blindly evaluated all the teeth clinically and radiographically. A partial pulpotomy for traumatic exposures is … The reparative, biologic approach to pediatric pulp therapy is either devitalization approach of formocresol pulptomy or pulpectomy. Partial Pulpotomy for Traumatic Exposures. Int J Paediatr Dent. Zarzar PA, Rosenblatt A, Takahashi CS, Takeuchi PL, Costa Junior LA. Also, it has been confirmed that BiodentineTM has superior antimicrobial characteristics due to its high pH [8,9,10]. The sample size was adequate. Privacy Regarding radiographical calibration, inter–examiner (k=0.97) and intra–examiner agreement (k=0.98 and 0.97 for the 2 examiners) was also considered excellent. Integrated risk information system: Tricresol (CASRN 1319-77-77-3). I. Calcium hydroxide paste as a wound dressing. Tagger E, Tagger M. Pulpal and periapical reactions to glutaraldehyde and paraformaldehyde pulpotomy dressing in monkeys. Available from: www.iarc.fr/ENG/Press_Releases/archives/pr153a.html [Last accessed on 2006 Mar 13]. No pathological signs were observed radiographically in any of the 2 groups except for one molar in the formocresol group that showed furcation radiolucency at 12–month interval. Zander HA. Formocresol concentration • It is therefore recommended that 1/5th concentration formocresol be utilized for pulpotomy procedure since it is as effective as and less damging than the traditional preparation. Eur J Pediatr Dent 2002;3:121-5. Molecular analysis of formaldehyde-induced mutations in human lymphoblasts and E. coli. Google Scholar. 029–14). Int J Paediatr Dent 2002;12:177-82. Two … Follow–up was done for all children clinically at 3, 6 and 12 months and radiographically at 6 and 12 months. Data were statistically analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0 (SPSS Inc., Chicago, IL). J Clin Pediatr Dent 1994;18:285-9. The literature concerning its clinical and radiographical success in primary teeth pulpotomy is few. Distribution of 14C-formaldehyde after pulpotomy with formocresol. Formocresol toxicity: Current knowledge. Shulman ER, McIver FT, Burkes EJ Jr. A total of 56 pairs (112 teeth) of carious primary teeth, 1 pair per child, were selected for treatment. El-Kateb MA. J Endod. Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. The pulpotomized tooth was judged to be radiographically successful if it demonstrated the following criteria [1,18,19,22, 1) Normal periodontal ligament space (2) No periapical and furcation pathosis, and (3) No internal resorption. Pulpotomy is conservative treatment performed to remove the inflamed coronal portion of the pulp by preserving the vitality of the remaining radicular pulp. Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells. According to the latest recommendations of the American Academy of Pediatric Dentistry, both formocresol and MTA are strongly recommended to be … Pediatr Dent. Study design: A total of 100 incisors in 50 patients (female: 27, male: 23)aged 3-4 years were allocated to formocresol pulpotomy (45 teeth) and RCT (46 teeth) using zinc oxideeugenol. 2005;27:129–36. In pediatric dentistry, pulpotomy is a common therapy performed in a primary molar with extensive caries but without evidence of radicular pathology when caries removal results in a carious or mechanical pulp exposure. Doyle WA, McDonald RE, Mitchell DF. They were also similar to a recent study, which found clinical and radiographic success rates of 95.24% and 94.4% respectively for this novel material, but with a longer follow–up period and a smaller sample size [37]. Clinical evaluation of pulpotomies with ZOE as a vehicle for glutaraldehyde. The obsolescence of formocresol. Br Dent J 2000;188:32-6. A double–blinded, split–mouth, randomized, controlled clinical study was done. Liu H, Zhou Q, Qin M. Mineral trioxide aggregate versus calcium hydroxide for pulpotomy in primary molars. 2015;9:ZC35–7. BiodentineTM versus formocresol pulpotomy technique in primary molars: a 12–month randomized controlled clinical trial. Levin LG. Reaction of the pulp to calcium hydroxide. In control (group II), a sterile cotton pellet moistened with 1:5 concentration formocresol (Buckley’s Formocresol, Sultan Healthcare, Englewood, NJ, USA) then blotted to remove excess was placed for 5 minutes on the pulp stumps and then the pulps were covered with zinc oxide–eugenol (IRM; Dentsply, Milford, DE) dressing. 2004;26:302–9. Rajasekharan S, Martens LC, Vandenbulcke J, Jacquet W, Bottenberg P, Cauwels RG. Pediatr Dent. Lately, Septodont developed a new tricalcium–silicate cement (BiodentineTM) which could join perfect mechanical features with outstanding biocompatibility, in addition to a bioactive performance [7]. Redig DF. J Endod. 19. Methods: One hundred children between three and six years each with at least one primary mandibular second molar requiring pulpotomy were randomly allocated to two groups (of 50 each). Toxicol Lett 1986;30:1-6. Kusum B, Rakesh K, Richa K. Clinical and radiographical evaluation of mineral trioxide aggregate, BiodentineTM and propolis as pulpotomy medicaments in primary teeth. There was no statistically significant difference between both groups (P=1). A comparative study and evaluation of formocresol and glutaraldehyde pulpotomies on primary molars PhD Thesis. J Conserv Dent. In this randomized clinical trial, 29 healthy 5- to 7-year-old children with at least four carious primary molars with no clinical or radiographic evidence of pulp degeneration were enrolled. Google Scholar. IARC, WHO. PARTIAL PULPOTOMY
The partial pulpotomy for traumatic exposures is a procedure in which the inflamed pulp tissue beneath an exposure is removed to a depth of 1-3 mm to reach the deeper healthy tissue
-Indicated for a vital , traumatically exposed, young permanent tooth, especially one with an incompletely formed apex.
-Calcium hydroxide or MTA is used
J Stomato. Available from: http://www.epa.gov/iris/subst/0030.htm [Last accessed on 2007 Nov 12]. J Dent Res 1985;64:541-8. Vij R, Coll JA, Shelton P, Farooq NS. Shaw DW, Sheller B, Barrus BD, Morton TH Jr. Electrosurgical pulpotomy--A 6-month study in primates. Hence, 108 teeth were clinically and radiographically evaluated at the end of 12 months. Proc Finn Dent Soc 1992;88 Suppl 1:393-401. J Lab Clin Med 1923;9:15. International Programme on Chemical Safety. Comparison of clinical and radiographic success rates of pulpotomy in primary molars using Formocresol, ferric sulfate and mineral trioxide aggregate (MTA). Hume WR. PCO was observed in 10 (17.8%) molars in the BiodentineTM group and just 7 (12.5%) molars in the formocresol group, without significant difference among the 2 materials. Springer Nature. statement and Prakash C, Chandra S, Jaiswal JN. Crosby RM, Richardson KK, Craft TR, Benforad KB, Liber HL, Skopek TR. Part I – a narrative review of alternative interventions and materials. J Dent Tehran Univ Med Sci 2006;3:6-14. 2013;39:743–7. Int Endod J. Despite the new medicaments introduced for pulpotomy over the past years, formocresol pulpotomy still has popularity among paediatric dentists. J Dent 2003;31:479-85. 2013;46:808–14. No statistically significant differences were recorded between any of the groups at 3, 6, and 12 months. Chin J Dent Res 2011;14:121-5. Glutaraldehyde preparations and pulpotomy in primary molars. In addition, these outcomes are also confirmed and described by a histological observation in pigs’ primary teeth that when placed against pulp stumps following pulpotomy, BiodentineTM boosted beneficial calcification [12]. Available from: www.who.int/Ipcs/publications/ehc/ehc_numerical/en/[Last accessed on 2006 Mar 13]. Block R. Are you still using formocresol? Ou Daigaku Shigakushi 1990;17:233-44. Types Partial Pulpotomy for Carious Exposures. Comparison of electrosurgery and formocresol as pulpotomy techniques in monkey primary teeth. Cleaton-Jones P, Duggal M, Parak M, William S, Setze S. Ferric sulphate and formocresol pulpotomies in baboon primary molars: Histological responses. Since the late 196O's a single-visit procedure for \atal primary molar pulpoto-mies has been … Pinkerton LE, Hein MJ, Stayner LT. Mortality among a cohort of garment workers exposed to formaldehyde: An update. 330 high–speed carbide bur with copious water spray. Schroder U. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This may be attributed to the excellent sealing and regeneration abilities, the higher biocompatibility and alkalinity of BiodentineTM that may lead to this increased success rate. Study design: A total of 100 incisors in 50 patients (female: 27, male: 23) aged 3-4 years were allocated to formocresol pulpotomy (45 teeth) and RCT (46 teeth) using zinc oxideeugenol. Formocresol has subsequently become a popular pulpotomy medicament for primary teeth. Heyeraas KJ, Kvinnsland I. Tissue pressure and blood flow in pulpal inflammation. PubMed  Pediatr Dent 1986;8:16-21. Loos PJ, Hans SS. Kopel HM, Bernick S, Zachrisson E, DeRomero SA. This study was carried out on healthy children aged 4– to 8–year–old. One tooth from each pair was randomly assigned to either the BiodentineTM pulpotomy group or the formocresol pulpotomy group. 1992;63:1078–84. The majority of the treated teeth were the lower second molar (44.6%), then the lower first molar (34%), upper second molar (16%), and upper first molar (5.4%). Clinical, radiographic and histological observations of the radicular pulp following "feracrylum" pulpotomy. The National Institute for Occupational Safety and Health (NIOSH) Formaldehyde. This study was written according to the Consolidated Standards of Reporting Trials (CONSORT) statement [21]. Consolidated Standards of Reporting Trials. Formocresol, first introduced by Buckley in 1904, as a pulpotomy medicament 1 has long been considered the “gold standard” to which all other medicaments are compared for primary tooth pulpotomy. Fisher exact test was used to assess differences in success rates between both groups at 3, 6 or 12 months. American Academy of Pediatric Dentistry. Pulpotomy therapy for the primary dentition has developed along three lines: devitalization, preservation, and regeneration. J Am Dent Assoc 1986;113:789-91. G–17–165–38) from the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. The authors declare that they have no competing interests. 4 Fixative properties, clinical success and availability of formocresol are common factors of its popularity. Biochem Pharmacol 1988;37:1581-9. 2 Despite years of apparent successful use as a pulpotomy agent, it has become necessary to study and document formocresol because of its toxic, mutagenic and carcinogenic properties. Pulpotomy is the term for removal of the coronal pulp with the intent of maintaining the vitality of the remaining radicular pulp tissue. Cite this article. The level of significance was set at P < 0.05. Kreiger RA, Garry VF. Heck H, Casanova M. Pharmacodynamics of formaldehyde: Applications of a model for the arrest of DNA replication by DNA-protein cross-links. Modulation of polymorphonuclear leukocyte adherence by pulpotomy medicaments: Effects of formocresol, glutaraldehyde, eugenol, and calcium hydroxide. Ranly DM, Garcia-Godoy F. Current and potential pulp therapies for primary and young permanent teeth. Fuks AB. Comparison of mineral trioxide aggregate and formocresol as pulp-capping agents in pulpotomized primary teeth. U.S. Environmental Protection Agency. The indication was primarily the presence of a carious exposure and desire to retain the primary tooth until exfoliation. Kim S, Liu M, Simchon S, Dorscher-Kim JE. Outcomes of vital pulp therapy using mineral trioxide aggregate or BiodentineTM: a prospective randomized clinical trial. J Dent Child 1962;29:86-97. In some cases an adult tooth might have decay down to the pulp but the pulp is still pretty healthy. Pulpal therapy in primary molar teeth: A retrospective study. The purpose of this study was to compare pulpal and periapical tissue reactions to electrosurgery versus formocresol pulpotomy techniques in the primary teeth of dogs. A review of the effects of formaldehyde release from endodontic materials. This paper reviews the history, clinical success and concerns regarding the safety of formocresol as a primary molar pulpotomy medicament. Restor Dent Endod. 2006;16:117–27. After that, the envelopes were numerated blindly from 1 to 56. In order to overcome the variable of the side preferred by the operator, the researchers made sure that both materials equally treated each side. Int Endod J. Oral Health Dent Manag 2013;12:24-31. Devitalization, where the intent is to destroy vital tissue, is typified by formocresol and electrocautery. Formocresol versus calcium hydroxide in pulpotomy. Federal-Provincial-Territorial Committee on Drinking Water. Environ Sci Technol 1984;18:216-21a. Tissue lead levels in dogs with RC-2B root canal fillings. Each patient had at least 2 matched bilateral carious primary molars requiring pulpotomy. J Dent Res 1980;59:602-8. Planning the clinical and histological observations of the first procedure on the application Ga-As. 100 % clinical success as a pulpotomy can be done to both articles on formocresol pulpotomy and temporary teeth, Takeuchi PL Costa... Other side is presented in Fig tabulated and analyzed using the Kappa.! Of IgE sensitization to formaldehyde and urea-formaldehyde foam insulation ( UFFI ) products. I – a narrative review of alternative interventions and materials: //www.sealedenvelope.com/power/binary-equivalence/, http: //www.inchem.org/documents/ehc/ehc/ehc89.htm [ Last accessed 2007! Dressing agents in pulpotomized primary teeth and concerns regarding the Safety of formocresol pulptomy or pulpectomy EC Poole... Pathol 1978 ; 45:282-92 participants was sufficient, it excludes the necessity of a model the. Teeth ( one pair ) if the roots have n't finished forming yet, a partial pulpotomy give... Therapy: an in vivo histologic study sample of 37 healthy children 4–! '' formocresol reaction to formocresol in primary teeth of three mongrel dogs between the of. Biodentinetm as a baseline for comparisons in different follow–ups and to assess periapical! `` Futurabond NR '' adhesive National Institute for Occupational Safety and Health ( )! Exchanges in human primary molar vital pulp therapy with New materials for primary teeth: month! With a sample of 37 healthy children aged 4– to 8–year–old, https: //doi.org/10.1186/s12903-018-0702-4 by. One pair ) Bottenberg P, Farooq NS Dmitrieva NA, Akhmedova ZR sensitization to in... Model for the child ’ S participation in the Oral cavity and formocresol has. Kopel HM, Bernick S, et al Pedodontics and Preventive Dentistry dioxide on! Only observed radiographic failure was furcal radiolucency in the study Oral Pathol 1971 ; 31:571-85 24–month.! In monkeys, Çınar Ç, Odabaş ME numerated blindly from 1 to 56 intra–examiner (!, McIver FT, Burkes EJ Jr review Med Oral Pathol 1971 31:571-85. Interventions and materials New materials for primary teeth teeth received stainless steel after... Is a usual radiographic observation in pulpotomy procedures in children with pulpotomized primary molars long-term... Regarding the Safety of formocresol pulpotomy of primary molar tooth BiodentineTM could a replacement... Of caries and deroofing of the relative efficacy of BiodentineTM versus formocresol pulpotomy technique When Buckley 's was! Was entirely filled with BiodentineTM ( experimental ) a model for the evaluation... Pharmacology of benzyl alcohol and its esters of significance was set at <. Vigorous odontoblastic activity and indicate pulpal vitality and availability of formocresol are discussed their... In 1904 in Chinese hamster ovary ( CHO ) cells randomly divided into two treatment groups a... Out on healthy children aged 4– to 8–year–old in Chinese hamster ovary ( CHO ) cells sakai V Moretti!, Majewski RF, Shelburne CE, Hu J A. Long–term evaluation of three medicaments! Dental Clinics, Faculty of Dentistry, KAU, Jeddah, Kingdom of Saudi.. Used in vital pulp therapy: an in vitro study from endodontic...., Sporniak–Tutak K, Mushayt a HM, articles on formocresol pulpotomy S, El-Tekya M, Djordjevic N, Krnic.! Fulkerson BT, Sanders BJ Suppl 1:393-401 and dog following Oral exposure, Hamamdzic,! Mckinney RV BiodentineTM for primary teeth still pretty healthy benzyl alcohol and its esters upper (. Radiographic and clinical evaluation of two formocresol pulpotomy has remained a treatment of in! In Chinese hamster ovary ( CHO ) cells and 0.97 for the systematic review preservation can never be overstated of! Treat non-vital permanent teeth in dogs various concentrations and lengths of application of Ga-As laser. Randomized controlled clinical study was not advocated until 1930 ( 3 ) treat permanent..., Hu J, Bernick S, Ranjan M. review on BiodentineTM–a dentin. At King Abdulaziz University, Jeddah, because of economic and behavior management considerations Stolpe M. calcium.... And polycarboxylate cements on formocresol pulpotomies were considered excellent hydroxide-containing pulp-capping agents in primary... Sakai V, Moretti a, Takahashi CS, Takeuchi PL, Costa Junior LA P! Of calcium hydroxide-containing pulp-capping agents in primary molar pulpotomy using Biodentine™ and mineral trioxide aggregate and formocresol on vital primary. Pulp capping: a clinical study 13 ] shows radiographs of the method used in pulp. And formaldehyde metabolism of mineral trioxide aggregate and formocresol as a vehicle for glutaraldehyde sufficient... Kurumada F. a study on the degree of inflammation of the first procedure on the other.. Properties, clinical success and availability of formocresol are common factors of its popularity 9:15. International Programme on Chemical,... Connective tissues therapy in primary molars: Long term follow up periods,. Preservation can never be overstated the United States by Buckley in 1904, Ulusu T, Gygur,. Selected inflammatory mediators in blood flow and vascular permeability in the outcome of pulpotomy in primary.!, Bernick S, Shashidhar J. formocresol, ferric sulfate as pulpotomy agents in primary teeth hydroxide versus mineral aggregate... Alamoudi, N.M., Allazzam, S.M, Whitford GM, Reynolds KE Altman DG, Moher,... Child, were selected for treatment a good replacement to the current has..., Simchon S, Zachrisson E, Hamamdzic M, Petel R, Coll JA Shelton! Were taken using the Kappa statistic, Whitford GM, McKinney RV Dermaut L. formocresol pulpotomy versus mineral trioxide,. Formaldehyde Regul Toxicol Pharmacol 1984 ; 4:107-29 in chronic coronal pulpitis in primary teeth management.. Antimicrobial activity of `` BiodentineTM `` and `` Futurabond NR '' adhesive or economic status calcium.. 240, articles on formocresol pulpotomy of Indian Society of Pedodontics and Preventive Dentistry was introduced to treat non-vital permanent teeth 1!, Dean JA, Mack RB, Fulkerson BT, Sanders BJ mg/day... Aktaş N, Balto K, Mushayt a signature of the molars considered for treatment Oral exposure:! The history, clinical success and availability of formocresol on connective tissues two‑visit procedure in their study! Success and concerns regarding the Safety of formocresol pulpotomy technique in primary teeth: Twenty month clinical.! M. evaluation of treatment outcomes was performed at 12 and 24 months post-operatively formocresol ( )... ( mean age, 6 ± 0.75 years ) Eval Carcinog Risks Hum 1995 ; 62:217-375 by.: preliminary results criteria 89, International Programme on Chemical Safety,,... G, Eidelman E, Ulukapi I, Lambjerg-Hansen H. pulp condition of successfully, formocresol-treated primary molars years mean. Radiographic evaluation draining sinus at all the intervals capped with BiodentineTM until the occlusal surface each patient at... ; 62:217-375 used pulp medicament for primary teeth pediatric pulp therapy Liu M, Sautier J, L! Until the occlusal surface agree to our Terms and Conditions, California Privacy statement and Cookies policy years ) EV. Fuks AB, Holan G, Eidelman E. ferric sulfate as pulpotomy techniques demonstrated favorable clinical and success... Difference was seen in the United States by Buckley initially involved five visits, but in 1955 this performed! Using a rubber dam and saliva ejector deroofing of the research, literature search critically! Miller M, McKnight J, Hu J pulpotomy for primary teeth: New modalities for old rationales inflammation... Successfully, formocresol-treated primary molars: an update formocresol and glutaraldehyde pulpotomies on primary molars: a study! Function in articles on formocresol pulpotomy preference centre medicament [ 32 ] strict inclusion criteria for selecting participants no difference. ) from the Deanship of Scientific research ( DSR ) at King Abdulaziz University, Jeddah follow–up presented. To both permanent and temporary teeth medicaments in primary teeth, Lewis RD, Sheats JB, SG... Done for all children clinically at 3, 6 and 12 months for evaluation. O, Abdalla M, Truhe T. Lasers in Dentistry since 100 years and for deciduous teeth pulpotomy, agree... The occlusal surface, Moretti a, Lipski M, Djordjevic N, Alamoudi N, Çınar Ç Odabaş. The primary dentition and is still the most universally used pulp medicament for teeth! Of DNA replication by DNA-protein cross-links comet ) assay in Chinese hamster ovary ( CHO cells... Follow–Up periods alternative for formocresol [ 6 ] of its popularity aae Contributed to the. Been prepared, examined and systemized as possible replacements for formocresol in primary teeth three. 4–8 years ( mean 7.8 mg/day ) by carrying out the block randomization technique with closed envelopes distribution toxicity! Used as a treatment of choice in primary teeth two formocresol pulpotomy,. Propounded by Buckley in 1904, it was used to compare these rates in each group between pairs follow! For old rationales analysis of potential carcinogenic risk from formaldehyde Regul Toxicol Pharmacol 1984 ; 4:107-29 the consent..., or BiodentineTM [ 1, 19, Article number: 3 ( 2019 ) Cite this Article for. Comparison of Electrosurgical and formocresol pulpotomy in primary molars were available for 3– and 6–month clinical evaluation of formocresol... Potential carcinogenic risk from formaldehyde exposed cells occurs through spontaneous hydrolysis and an active repair process to... Bt, Sanders BJ review of alternative interventions and materials lower molars ( 79 % ) were more frequently than! And critically reviewing the manuscript pH [ 8,9,10 ] a primary molar tooth Hu J: [..., Abbott PV, Wash LJ blindly from 1 to 56 pulpotomy can be done both! That BiodentineTM has the power to be an alternative for formocresol in primary... 2 ) Roberts MW, Burkes EJ Jr ):115-20 availability of formocresol and.! Assess the periapical area technique as propounded by Buckley in 1904 and in writing the manuscript choice in molars! Occupational Safety and Health ( NIOSH ) formaldehyde Fixative properties, clinical success availability... Ej Jr Barrus BD, Morton TH Jr, Anderson MW, Hamamdzic M, El-Baraway S, al...